As a result of this gene pair or gene singular inheritance, over-expressed circular blotches or deposits of the amyloid peptide chain (a three-dimensionally shaped protein), equal to approx. 1/10th of a millimeter in diameter become variously deposited frequently in Alzheimer patients in and around the hypocampus-medial temporal lobe area of the brain starting as early as the late 20’s of a tested positive patient’s life.
Interestingly, repetitive type motor memories such as riding a bike, or swimming, or painting are not affected by such synaptic blotches because in the Alzheimer’s patient’s brain, those areas that are infected by Alzheimer’s disease tend to be those synapse of neurons engaged in the higher cognitive skills such as short to long term memory movement in and around the hypocampus-medial temporal lobe.
Motor skill memory, on the other hand, is generally processed by the brain in a totally unrelated area of the cerebral cortex plane.
Enter Scientific American to Explain Further
In older brains, however, THC seems to have a protective effect. Campbell’s findings indicate that the biochemistry of neurons changes as the cells mature. The role of endocannabinoids shifts to regulate different functions—most important, assisting in the survival of aged neurons. In patients with Alzheimer’s disease, THC protects neurons from death in several ways. THC boosts depleted levels of the neurotransmitter acetylcholine, which, when diminished, contributes to the weakened mental function in Alzheimer’s patients. THC also suppresses the toxic effects of the so-called a-beta protein that may kill neurons in Alzheimer’s disease. It stimulates secretion of neuron growth by promoting substances such as brain-derived neurotrophic factor, and it dampens release of the excitatory neurotransmitter glutamate, which kills neurons by overstimulation. THC and other cannabinoids also have powerful anti-inflammatory and antioxidant actions that protect neurons from immune system attack.
Source: Alzheimer Foundation
Compile’d by: ♑ Robert Hempaz, PhD. Trichometry™
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- Tau-induced memory loss in Alzheimer’s mice is reversible (physorg.com)
- Tau-induced memory loss in Alzheimer’s mice is reversible; Study raises hopes for the development of effective therapies (sciencedaily.com)
- Tau-induced memory loss in Alzheimer’s mice is reversible (scienceblog.com)
- Tau-induced memory loss in Alzheimer’s mice is reversible (eurekalert.org)
- Second member in Alzheimer’s toxic duo identified (sciencedaily.com)